• Quais são os resultados? (importância)
  • Quais serão os aumentos de despesas e desfechos clínicos de cada estratégia?
  • Existe diferenças entre os sub-grupos relacionados com os custos e desfechos clínicos?
  • Qual a margem de erro dos resultados?

Drummond MF, Richardson WS, O'Brien BJ, Levine M, Heyland D. Users' guides to the medical literature. XIII. How to use an article on economic analysis of clinical practice. A. Are the results of the study valid? Evidence-Based Medicine Working Group. JAMA 1997 May 21;277(19):1552-7. Disponível em: URL: http://www.cche.net/text/usersguides/economic.asp

O'Brien BJ, Heyland D, Richardson WS, Levine M, Drummond MF. Users' guides to the medical literature. XIII. How to use an article on economic analysis of clinical practice. B. What are the results and will they help me in caring for my patients? Evidence-Based Medicine Working Group. JAMA 1997 Jun 11;277(22):1802-6. [Published erratum appears in JAMA 1997 Oct 1;278(13):1064] Disponível em: URL: http://www.cche.net/text/usersguides/economic.asp

The GUSTO Investigators. An international randomized controlled trial comparing four thrombolytic strategies for acute myocardial infarction. New Eng J Med 1993;329:673-682.

Mark DB, Hlatkly MA, Califf RM, Naylor CD, Lee KL, et al. Cost-effectiveness of thrombolytic therapy with tissue plasminogen activator as compared with streptokinase for acute myocardial infarction. New Eng J Med 1995;332;1418-1424.

• Entender quais são os princípios adotados para para analisar riscos e custos;
• Entender o ponto de vista do doente ao esperar desfechos clínicos semelhantes;
• Entender como podem ser avaliado a espera de custos semelhantes.

More Informative Abstracts Revisited. Haynes RB, Mulrow CD, Huth EJ, Altman DG, Gardner MJ. Ann Intern Med 1990;113:69-76. Disponível em: URL: http://www.acponline.org/journals/resource/90aim.htm

Greenhalgh T. How to read a paper. Papers that tell you what things cost (economic analyses). BMJ 1997 Sep 6;315(7108):596-9 . Disponível em: URL: http://www.bmj.com/collections/read.shtml

Detsky AS, Naglie IG. A clinician's guide to cost-effectiveness analysis. Ann Intern Med 1990;113-147-54.

http://www.cebm.net/levels_of_evidence.asp
Levels of evidence and grades of recommendation, Centre for Evidence-Based Medicine, Oxford, UK.